An introduction to systemas biology. "Design principles of biological circuits."

Sinopsis
Written for students and researchers, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological systems. It highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade.

Features:

Includes seven new chapters
The new edition has 189 exercises, the previous edition had 66
Offers new examples relevant to human physiology and disease

Table of Contents

Part One: Network Motifs

Chapter 1. Transcription Networks basic concepts

Chapter 2. Autoregulation

Chapter 3. The Feed Forward Loop

Chapter 4. Temporal Programs and the Global Structure of Transcription Networks

Chapter 5. Positive Feedback, Bistability and Memory

Chapter 6. How to Build a Biological Oscillator

Part Two: Robustness

Chapter 7. Kinetic Proofreading and Conformational Proofreading

Chapter 8. Robust Signalling

Chapter 9. Chemotaxis

Chapter 10. Fold-change Detection

Chapter 11. Dynamical Compensation and Mutal Resistance in Tissues

Chapter 12. Robust Spatial Patterning in Development.

Part Three: Optimality

Chapter 13. Optimal Gene Circuit Design

Chapter14. Multi-objective Optimality in Biology

Chapter 15. Modularity